Pharmacological inhibition of Septins with Forchlorfenuron attenuates thrombus formation in experimental thrombotic mice models with modulating multiple signaling pathways in platelets
FCF showed preferences in attenuating pathological thrombus formation, apart from physiological haemostasis, with possible mechanisms to prevent cytoskeletal remodelling and signal transduction of AKT, ERK1/2 and VASP signalling pathways, suggesting that Septin may serve as a promising target for the prevention and treatment of thrombotic diseases.
Authors
- Feng Zhao (ORCID: https://orcid.org/0000-0002-7959-0394)
- Habib Alam (ORCID: https://orcid.org/0009-0003-6138-2014)
- Minghui Yan (ORCID: https://orcid.org/0000-0002-9628-4938)
- Lei Shi (ORCID: https://orcid.org/0000-0001-9100-897X)
- Yuanhua Qin
- Jun Wu (ORCID: https://orcid.org/0000-0003-1834-9596)
- Reyisha Tuerhong (ORCID: https://orcid.org/0009-0006-6773-983X)
- Zhen Hao
- Zhen Zhang
- Luying Zhang (ORCID: https://orcid.org/0000-0002-0796-9522)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1016/j.jare.2024.08.006
- Citations
- 2
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Dalian Medical University