Signal Amplification by Reversible Exchange and its Translation to Hyperpolarized Magnetic Resonance Imaging in Biomedicine
Abstract Hyperpolarized magnetic resonance imaging (HP‐MRI) has emerged as a powerful tool in molecular imaging, providing in vivo , real‐time insights into metabolic pathways without ionizing radiation. Signal Amplification by Reversible Exchange (SABRE) represents a promising hyperpolarization technique, leveraging parahydrogen to enhance MRI signals. In this concept, we delineate the evolution of SABRE and landmark papers that have enabled us recently to produce biocompatible and low‐cost hyperpolarized pyruvate within minutes for in vivo metabolic imaging, showcasing SABRE′s potential for preclinical and near‐future clinical settings. Looking ahead, with ongoing efforts focused on optimizing polarizer technology and expanding applications beyond pyruvate, we envision SABRE as a key player in the research and application of HP‐MRI due to its simplicity and throughput.
Authors
- Henri de Maissin (ORCID: https://orcid.org/0000-0003-3505-1572)
- Andreas Benjamin Schmidt (ORCID: https://orcid.org/0000-0001-8944-7463)
- Jan‐Bernd Hövener (ORCID: https://orcid.org/0000-0001-7255-7252)
- Luca Nagel (ORCID: https://orcid.org/0000-0002-5530-6264)
- Philipp R. Groß (ORCID: https://orcid.org/0009-0003-5044-3109)
- Thomas Reinheckel (ORCID: https://orcid.org/0000-0001-9866-9105)
- Franz Schilling (ORCID: https://orcid.org/0000-0001-5239-4628)
- Stephan Knecht (ORCID: https://orcid.org/0000-0002-8487-4324)
- Eduard Y. Chekmenev (ORCID: https://orcid.org/0000-0002-8745-8801)
- Ilai Schwartz (ORCID: https://orcid.org/0009-0001-5621-859X)
- Stefan Petersen (ORCID: https://orcid.org/0009-0009-3893-4101)
Institutions
- OmniVision Technologies (Germany) (DE)
- University of Freiburg (DE)
- German Cancer Research Center (DE)
- Wayne State University (US)
- Heidelberg University (DE)
- University Medical Center Freiburg (DE)
- TUM Klinikum (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- The Barbara Ann Karmanos Cancer Institute (US)
- Michigan United (US)
- University Hospital Schleswig-Holstein (DE)
- Technical University of Munich (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Analysis & Sensing
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1002/anse.202400039
- Citations
- 6
- Primary Topic
- Advanced NMR Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.44
Funders
- National Science Foundation
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Christian-Albrechts-Universität zu Kiel
- Bayerische Akademie der Wissenschaften
- Deutschen Konsortium für Translationale Krebsforschung
- Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg
- National Institute of Biomedical Imaging and Bioengineering