Lactate dehydrogenase A (LDHA)-mediated lactate generation promotes pulmonary vascular remodeling in pulmonary hypertension
Thus, LDHA-mediated lactate production promotes pulmonary vascular remodeling in PH by activating Akt signaling pathway, suggesting the potential role of LDHA in regulating the metabolic reprogramming and vascular remodeling in PH.
Authors
- Xingbing Li (ORCID: https://orcid.org/0000-0002-1683-4996)
- Qing Zhang (ORCID: https://orcid.org/0000-0002-0495-3920)
- Shuo Wang (ORCID: https://orcid.org/0000-0003-4919-5390)
- Fengxian Wang (ORCID: https://orcid.org/0000-0001-5722-8389)
- Daiqian Wu
- Zhen Zhang (ORCID: https://orcid.org/0000-0002-0647-4253)
Institutions
- Army Medical University (CN)
- Daping Hospital (CN)
- Third People's Hospital of Chengdu (CN)
- First People's Hospital of Chongqing (CN)
- Southwest Jiaotong University (CN)
- Chongqing University of Technology (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1186/s12967-024-05543-7
- Citations
- 27
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 11.31
Funders
- Natural Science Foundation of Sichuan Province