Exploration of the intracellular chiral metabolome in pediatric BCP-ALL: a pilot study investigating the metabolic phenotype of IgH locus aberrations
The findings of this study have contributed to the understanding that the chiral metabolome plays a role in the poor prognosis observed in an exceptionally rare patient cohort. The findings include elevated D-amino acid incorporation in the IgH group, the emergence of several unknown, potentially enantiomeric, metabolites, and insights into metabolic pathways that all warrant further exploration.
Authors
- Valeria Impedovo (ORCID: https://orcid.org/0000-0002-2166-4303)
- Meghan Collins (ORCID: https://orcid.org/0000-0002-6201-9298)
- Chakkarai Sathyaseelan
- Ruggiero Gorgoglione (ORCID: https://orcid.org/0000-0002-9860-0914)
- S. Stephen Yi (ORCID: https://orcid.org/0000-0003-0047-8103)
- Alessia Lodi (ORCID: https://orcid.org/0000-0002-2104-5713)
- Xingxin Pan (ORCID: https://orcid.org/0000-0002-4429-4878)
- Stefano Tiziani
Institutions
- Livestrong Foundation (US)
- Dell Children's Medical Center of Central Texas (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-08-05
- DOI
- https://doi.org/10.3389/fonc.2024.1413264
- Citations
- 2
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 1.09
Funders
- Cain Foundation
- National Institutes of Health
- Dell Medical School, University of Texas at Austin
- Hyundai Hope On Wheels