Long-term natural history of ellipsoid zone width in<i>USH2A</i>-retinopathy
EZ width follows an exponential decline in <i>USH2A</i>-retinopathy. Compared with raw EZ width decline rate, log-transformed EZ width decline rate may be a superior endpoint for clinical trials. Syndromic eyes exhibit an earlier onset of macular EZ width loss but progress at comparable rates to non-syndromic eyes.
Authors
- Joshua L. Warren (ORCID: https://orcid.org/0000-0002-6274-6970)
- Michael Heyang (ORCID: https://orcid.org/0000-0002-5960-949X)
- Liangbo L. Shen (ORCID: https://orcid.org/0000-0002-1823-0854)
- Jacque L. Duncan (ORCID: https://orcid.org/0000-0002-9593-6412)
- Mariya Moosajee (ORCID: https://orcid.org/0000-0003-1688-5360)
- Paulina Ocieczek
- Lucian V. Del Priore
Institutions
- Moorfields Eye Hospital NHS Foundation Trust (GB)
- University of California, San Francisco (US)
- Yale University (US)
- Moorfields Eye Hospital (GB)
- University College London (GB)
Publication Details
- Journal
- British Journal of Ophthalmology
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1136/bjo-2024-325323
- Citations
- 2
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Research to Prevent Blindness
- Yale University
- Wellcome Trust
- National Institutes of Health
- University of California, San Francisco
- National Eye Institute