Morphofunctional characteristics of the liver after administration of ascorbic acid in a model of radiation hepatitis

Introduction: Radiation-induced hepatitis develops both with direct irradiation of malignant neoplasms of the liver and abdominal organs. An important task of modern radiobiology is the development of methods for the prevention of acute and chronic post-radiation complications, for example, the injections of protectors. Materials and methods: Wistar rats (n = 40) were divided into groups: I – control (n = 10); II (n = 10) – electron irradiation; III (n = 10) – injection of ascorbic acid before electron irradiation; IV (n = 10) – injection of ascorbic acid. A biochemical blood test, oxidative status analysis, morphological, morphometric and statistical studies were carried out. Results: In group III, a less pronounced change in the main morphological and morphometric parameters was noted compared to group II; indicators of biochemical analysis and oxidative status approached control values. Conclusions: According to the results of the study, it was revealed that local irradiation with electrons after a week leads to disruption of the histoarchitecture of the liver, and the injection of ascorbic acid reduces the depth and range of radiation-induced hepatitis.