Basal cell carcinoma in the scrotal region of a young male patient: atypical presentation

Basal cell carcinoma (BCC) is the most common type of malignant cutaneous neoplasm, followed by squamous cell carcinoma and melanoma.Body areas most exposed to light, such as the head and neck, are most affected by BCC, due to cellular DNA damage caused by ultraviolet radiation (UVR).The effects of UVR are cumulative throughout life, explaining the higher incidence of BCC in middle-aged and elderly individuals.However, incidence has been increasing among young people, and in some cases, BCC occurs in areas typically not exposed to light.Recent findings on pathogenesis highlight the involvement of specific genetic alterations, especially in sporadic cases among young patients.Here, we report a BCC in a young patient an unusual location (scrotal skin), emphasizing the importance of thorough dermatological evaluation and considering possible alternative pathogenic mechanisms for this disease.

Authors

Publication Details

Journal
Portuguese Journal of Dermatology and Venereology
Published
2024-08-05
DOI
https://doi.org/10.24875/pjdv.24000035
Primary Topic
Cancer and Skin Lesions
Type
article
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article

Basal cell carcinoma in the scrotal region of a young male patient: atypical presentation

Eduardo C.N. Constantino, Lucas S. Madureira, Liz S. Gea, Paula F. M. Madureira et al.
Portuguese Journal of Dermatology and Venereology
Cancer and Skin Lesions
article

Basal cell carcinoma in the scrotal region of a young male patient: atypical presentation

Eduardo C.N. Constantino, Lucas S. Madureira, Liz S. Gea, Paula F. M. Madureira, Vivian W. Lederman, Julia C. K. El Dib
article en

Abstract

Basal cell carcinoma (BCC) is the most common type of malignant cutaneous neoplasm, followed by squamous cell carcinoma and melanoma.Body areas most exposed to light, such as the head and neck, are most affected by BCC, due to cellular DNA damage caused by ultraviolet radiation (UVR).The effects of UVR are cumulative throughout life, explaining the higher incidence of BCC in middle-aged and elderly individuals.However, incidence has been increasing among young people, and in some cases, BCC occurs in areas typically not exposed to light.Recent findings on pathogenesis highlight the involvement of specific genetic alterations, especially in sporadic cases among young patients.Here, we report a BCC in a young patient an unusual location (scrotal skin), emphasizing the importance of thorough dermatological evaluation and considering possible alternative pathogenic mechanisms for this disease.

Portuguese Journal of Dermatology and VenereologyVol. 83(1)
Gender equality
Openalex Percentile: Top 75%
Cancer and Skin Lesions
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Basal cell carcinoma in the scrotal region of a young male patient: atypical presentation — Eduardo C.N. Constantino, Lucas S. Madureira, et al. · Portuguese Journal of Dermatology and Venereology (2024) | TGRS Research Map | TGRS