Fluoxetine accelerates epileptogenesis and magnifies disease severity in a rat model of acquired epilepsy
Our studies demonstrate that, using a model exhibiting spontaneous seizures, epileptogenesis is accelerated and magnified by fluoxetine, an effect that may be related to more severe pathological neuroplasticity. The differential influence of fluoxetine on behavior indicates that different circuitry and mechanisms are responsible for these comorbidities. These findings suggest that caution should be exercised when prescribing SSRI antidepressants to people at risk of developing epilepsy.
Authors
- Michael Salzberg
- Terence John O'Brien (ORCID: https://orcid.org/0000-0002-7198-8621)
- Nigel C. Jones (ORCID: https://orcid.org/0000-0002-1080-8439)
- Ezgi Öztürk
- Flávia Gomes (ORCID: https://orcid.org/0000-0003-4305-4693)
- Gabi Dezsi
- Margaret J. Morris (ORCID: https://orcid.org/0000-0003-2285-5117)
- Matthew R. Hudson (ORCID: https://orcid.org/0000-0001-5016-735X)
- Davy Wong
- Gabriella Martello
Institutions
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- UNSW Sydney (AU)
- Monash University (AU)
Publication Details
- Journal
- Epilepsia
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1111/epi.18080
- Citations
- 3
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Monash University
- Medical Research Council
- National Health and Medical Research Council