Variation of LDL cholesterol in response to the replacement of saturated with unsaturated fatty acids: a nonrandomized, sequential dietary intervention; the Reading, Imperial, Surrey, Saturated fat Cholesterol Intervention (“RISSCI”-1) study
These findings support the efficacy of United Kingdom SFA dietary guidelines for the overall lowering of serum LDL cholesterol but showed marked variation in LDL cholesterol response. Further identification of the determinants of this variation will facilitate targeting and increasing the efficacy of these guidelines. The RISSCI-1 study was registered with ClinicalTrials.Gov (No. NCT03270527).
Authors
- Laury Sellem (ORCID: https://orcid.org/0000-0002-2697-997X)
- E. Ozen (ORCID: https://orcid.org/0000-0001-6203-7018)
- H. Ayyad
- Jonathan R. Swann (ORCID: https://orcid.org/0000-0002-6485-4529)
- A. Koutsos (ORCID: https://orcid.org/0000-0002-2952-2502)
- M. Denise Robertson (ORCID: https://orcid.org/0000-0001-5461-9544)
- Gloria Hoi Yan Wong (ORCID: https://orcid.org/0000-0002-1331-942X)
- Kim G. Jackson (ORCID: https://orcid.org/0000-0002-0070-3203)
- Julie A. Lovegrove (ORCID: https://orcid.org/0000-0001-7633-9455)
- Rona Antoni (ORCID: https://orcid.org/0000-0002-4193-2328)
- Barbara A. Fielding
- Bruce A. Griffin
Institutions
- University of Surrey (GB)
- University of Southampton (GB)
- University of Reading (GB)
Publication Details
- Journal
- American Journal of Clinical Nutrition
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1016/j.ajcnut.2024.07.032
- Citations
- 5
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- University of Reading
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council