Ru(II)-Catalyzed C–H Activation/[4+2] Annulation of Sulfoxonium Ylide with Maleimide: Access to Fused Benzo[<i>e</i>]isoindole-1,3,5-trione
A ruthenium-catalyzed C-H activation and a concomitant [4+2] annulation of sulfoxonium ylide with maleimide have been demonstrated. This tandem reaction results in the formation of fused benzo[<i>e</i>]isoindole-1,3,5-trione. The method employs mild conditions and is free of metal oxidants. The reaction pathway predominantly involves protodemetalation over β-hydride elimination due to the lack of <i>syn</i> β-hydrogens.
Authors
- Vimlesh Kumar (ORCID: https://orcid.org/0000-0003-2206-4905)
- Dattatraya H. Dethe (ORCID: https://orcid.org/0000-0003-2734-210X)
- Rahul Das (ORCID: https://orcid.org/0009-0007-6790-4636)
Institutions
- Indian Institute of Technology Kanpur (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1021/acs.orglett.4c02175
- Citations
- 9
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.25
Funders
- Indian Institute of Technology Kanpur
- Council of Scientific and Industrial Research, India
- Science and Engineering Research Board