Induction of tau pathology and motor dysfunction in mice by urinary exosomes from progressive supranuclear palsy patients
Our findings indicate that urinary exosomes from PSP-RS patients can induce tau pathology and trigger PSP-like motor symptoms in mice. This leads to the hypothesis that exosomes may play a role in the pathogenesis of PSP.
Authors
- Chi Qin (ORCID: https://orcid.org/0009-0007-5903-7982)
- Dongxiao Liang (ORCID: https://orcid.org/0000-0002-4869-6284)
- Jingwen Zhang (ORCID: https://orcid.org/0000-0002-6064-1374)
- Han Liu (ORCID: https://orcid.org/0009-0007-0130-7898)
- Qingyong Zhu (ORCID: https://orcid.org/0000-0002-6404-4745)
- Junfang Teng (ORCID: https://orcid.org/0009-0009-8149-499X)
- Yongkang Chen (ORCID: https://orcid.org/0000-0002-1969-6226)
- Ruoqi Jin
- Qiusha Li
- Rui Zhang (ORCID: https://orcid.org/0009-0001-2573-7055)
Institutions
- Zhengzhou University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1016/j.brainresbull.2024.111046
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- National Natural Science Foundation of China