Loss of Nup155 promotes high fructose-driven podocyte senescence by inhibiting INO80 mRNA nuclear export
High fructose induces podocyte senescence by decreasing Nup155 to inhibit INO80 mRNA nuclear export. Ferulic acid targeting Nup155 may be a potential strategy to prevent high fructose-induced podocyte senescence.
Authors
- Ling‐Dong Kong
- Lei Fang (ORCID: https://orcid.org/0000-0002-2582-4845)
- Li Chen (ORCID: https://orcid.org/0009-0007-6683-0102)
- Zixuan Wang (ORCID: https://orcid.org/0000-0002-0854-5895)
- Chengzhi Wang (ORCID: https://orcid.org/0000-0001-7456-6099)
- Tangdi Xu
Institutions
- Nanjing Drum Tower Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1016/j.jare.2024.08.007
- Citations
- 6
- Primary Topic
- Diet, Metabolism, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 2.15
Funders
- National Natural Science Foundation of China
- National Aerospace Science Foundation of China
- State Key Laboratory of Pharmaceutical Biotechnology
- National Key Research and Development Program of China
- National Key Clinical Specialty Discipline Construction Program of China
- National Key Research and Development Program of China Stem Cell and Translational Research