Causal relationship between the gut microbiota, immune cells, and coronary heart disease: a mediated Mendelian randomization analysis
An increase in the abundance of g__Desulfovibrio.s__Desulfovibrio_piger leads to an increase in the amount of EM DN (CD4-CD8-) %T cells, and an increase in the amount of EM DN (CD4-CD8-) %T cells reduces the risk of developing CHD. Our study provides some references for reducing the incidence of CHD by regulating GM and immune cells.
Authors
- Feifei Yang (ORCID: https://orcid.org/0000-0002-8753-363X)
- Liwen Zhang (ORCID: https://orcid.org/0000-0002-3826-0639)
- Guixin He (ORCID: https://orcid.org/0009-0009-9041-6467)
- Ziyi Zhu (ORCID: https://orcid.org/0009-0008-4417-2644)
- Ling-yun Liu (ORCID: https://orcid.org/0000-0003-3154-2219)
- Bin Ouyang (ORCID: https://orcid.org/0000-0001-8735-4335)
- Hui Song
- Weizhi Tang
- Wei-bin Qin
Institutions
- Guangxi University (CN)
- Guangxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-08-05
- DOI
- https://doi.org/10.3389/fmicb.2024.1449935
- Citations
- 4
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.96
Funders
- Guangxi University of Chinese Medicine
- Division of Graduate Education