Electrochemical-induced phosphorylation of arenols and tyrosine containing oligopeptides
A disclosed technique employs electrochemical dehydrogenative cross-coupling to create organophosphates, utilizing phosphites compounds with arenols. Inorganic iodide salts serve dual roles as redox catalysts and electrolytes in an undivided cell, omitting the need for external oxidants or bases. Initial mechanistic investigations indicate the reaction unfolds via an electro-oxidative radical pathway, facilitating the formation of P-O bonds, leading to the generation of oxygen radicals in the formation of acetylaminophenol. This environmentally friendly approach offers excellent tolerance to various functional groups, achieves high yields (up to 95% isolated yield), and accommodates a wide range of substrates, showcasing its utility for practical synthesis applications.
Authors
- Pan Wu (ORCID: https://orcid.org/0000-0001-8339-4495)
- Rong Sun (ORCID: https://orcid.org/0000-0003-4269-7056)
- Wenbin Du (ORCID: https://orcid.org/0000-0002-7401-1410)
- Tianhao Chang (ORCID: https://orcid.org/0000-0002-6230-3328)
- Haoyang Jiang
- Yue Weng (ORCID: https://orcid.org/0000-0001-9126-3321)
- Yuling Zhou (ORCID: https://orcid.org/0009-0007-1340-808X)
- Chaochao Zhang (ORCID: https://orcid.org/0000-0001-7374-6602)
- Fan Hu (ORCID: https://orcid.org/0000-0001-9832-2654)
- Dingyu Li
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Hubei University (CN)
Publication Details
- Journal
- iScience
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1016/j.isci.2024.110487
- Citations
- 5
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- National Natural Science Foundation of China
- National Aerospace Science Foundation of China
- State Key Laboratory of Water Resources and Hydropower Engineering Science
- Engineering and Technology Research Center of Liupanshan Resources