Impact of Age on Pharmacogenomics and Treatment Outcomes of B-Cell Acute Lymphoblastic Leukemia
Our results provide pharmacogenomic insights into age-related disparities in ALL cure rates and identify leukemia prognostic features for treatment individualization across age groups.
Authors
- Seth E. Karol (ORCID: https://orcid.org/0000-0001-8113-8180)
- Wendy Stock (ORCID: https://orcid.org/0000-0002-8349-9200)
- Mary V. Relling (ORCID: https://orcid.org/0000-0002-3720-9591)
- Mignon L. Loh (ORCID: https://orcid.org/0000-0003-4099-4700)
- William E. Evans (ORCID: https://orcid.org/0000-0002-0357-7169)
- Steven Mitchell Kornblau (ORCID: https://orcid.org/0000-0002-5990-9548)
- Ching‐Hon Pui (ORCID: https://orcid.org/0000-0003-0303-5658)
- Nitin Jain (ORCID: https://orcid.org/0000-0003-0114-8384)
- Marina Konopleva (ORCID: https://orcid.org/0000-0002-9347-2212)
- Shawn H.R. Lee (ORCID: https://orcid.org/0000-0002-7161-3782)
- Yoshihiro Gocho (ORCID: https://orcid.org/0000-0001-8136-0187)
- Wenjian Yang (ORCID: https://orcid.org/0000-0002-7305-5649)
- Sima Jeha (ORCID: https://orcid.org/0000-0003-2835-5869)
- Kathryn G. Roberts (ORCID: https://orcid.org/0000-0001-7626-4043)
- Charles Grenfell Mullighan (ORCID: https://orcid.org/0000-0002-1871-1850)
- Elias Jabbour (ORCID: https://orcid.org/0000-0003-4465-6119)
- Satoshi Yoshimura (ORCID: https://orcid.org/0000-0003-3490-2101)
- Jun J. Yang (ORCID: https://orcid.org/0000-0002-0770-9659)
- Allen Eng Juh Yeoh (ORCID: https://orcid.org/0000-0002-6454-976X)
- Hiroto Inaba (ORCID: https://orcid.org/0000-0003-0605-7342)
- Mark Robert Litzow (ORCID: https://orcid.org/0000-0002-9816-6302)
- Kristine R. Crews (ORCID: https://orcid.org/0000-0002-7558-558X)
- Zhenhua Li (ORCID: https://orcid.org/0000-0002-3623-6571)
- Jiyang Yu (ORCID: https://orcid.org/0000-0003-1244-4429)
- Caner Saygin (ORCID: https://orcid.org/0000-0003-1315-0377)
- Elisabeth Paietta
Institutions
- Seattle Children's Hospital (US)
- Albert Einstein College of Medicine (US)
- St. Jude Children's Research Hospital (US)
- Montefiore Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- National University of Singapore (SG)
- University of Chicago (US)
- Mayo Clinic in Arizona (US)
- National University Health System (SG)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1200/jco.24.00500
- Citations
- 15
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 8.14
Funders
- Amgen
- Pfizer
- Sanofi
- Actinium Pharmaceuticals
- Jazz Pharmaceuticals
- American Lebanese Syrian Associated Charities
- BeiGene
- Astellas Pharma
- Servier
- National Institutes of Health