Directionality of HLA-DP permissive mismatches improves risk prediction in HCT for acute leukemia and MDS
HLA-DP permissive mismatches can be assigned a direction according to their immunopeptidome divergence across core and noncore subsets. Noncore permissive graft-versus-host mismatches show significantly reduced risks of relapse without increased nonrelapse mortality compared with allele-matched pairs.
Authors
- Nicolaus Martin Kröger (ORCID: https://orcid.org/0000-0001-5103-9966)
- Liesbeth C. de Wreede (ORCID: https://orcid.org/0000-0002-7667-9369)
- Marie Robin (ORCID: https://orcid.org/0000-0003-1388-9876)
- Esteban Arrieta‐Bolaños (ORCID: https://orcid.org/0000-0002-3696-5803)
- Urpu Salmenniemi (ORCID: https://orcid.org/0009-0002-2053-3384)
- Éric Deconinck (ORCID: https://orcid.org/0000-0002-6006-8088)
- Katharina Fleischhauer (ORCID: https://orcid.org/0000-0002-5827-8000)
- Anne Huynh (ORCID: https://orcid.org/0000-0001-8462-6198)
- Joost G.K. van der Hem (ORCID: https://orcid.org/0000-0003-3111-4249)
- Claude‐Eric Bulabois (ORCID: https://orcid.org/0000-0002-0214-7431)
- Jorinde D. Hoogenboom
- Ibrahim Yakoub‐Agha (ORCID: https://orcid.org/0000-0003-4524-8782)
- Florent Malard (ORCID: https://orcid.org/0000-0002-3474-0002)
- Peter van Balen (ORCID: https://orcid.org/0000-0002-9670-4664)
- Tobias Gedde‐Dahl (ORCID: https://orcid.org/0000-0002-3037-5378)
- Eleni Tholouli
- Annalisa Ruggeri (ORCID: https://orcid.org/0000-0002-7261-2765)
- Édouard Forcade (ORCID: https://orcid.org/0000-0002-8873-2868)
- Lars L. J. van der Burg (ORCID: https://orcid.org/0000-0003-2359-828X)
- Charles Crawley
Institutions
- Leiden University (NL)
- Oslo University Hospital (NO)
- Université de Bordeaux (FR)
- Universität Hamburg (DE)
- Université de Lille (FR)
- Leiden University Medical Center (NL)
- Manchester Royal Infirmary (GB)
- Centre Hospitalier Universitaire de Lille (FR)
- Sorbonne Université (FR)
- European Society for Blood and Marrow Transplantation (NL)
- Hôpital Saint-Antoine (FR)
- University Medical Center Hamburg-Eppendorf (DE)
- Essen University Hospital (DE)
- Hôpital Privé Jean Mermo (FR)
- IRCCS Ospedale San Raffaele (IT)
- Hôpital Saint-Louis (FR)
- Addenbrooke's Hospital (GB)
- Deutsche Knochenmarkspenderdatei (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Blood
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1182/blood.2024024351
- Citations
- 10
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 4.54