Addition of Metastasis-Directed Therapy to Systemic Therapy for Oligometastatic Pancreatic Ductal Adenocarcinoma (EXTEND): A Multicenter, Randomized Phase II Trial
This study supports the addition of MDT to systemic therapy for patients with oligometastatic PDAC. Induction of systemic immunity is a possible mechanism of benefit. These results warrant confirmatory trials to refine treatment strategy and provide external validation.
Authors
- Rachael Martin (ORCID: https://orcid.org/0000-0002-3866-6823)
- L Perles (ORCID: https://orcid.org/0000-0002-5326-1998)
- Matthew H. G. Katz (ORCID: https://orcid.org/0000-0003-3870-6968)
- Emma B. Holliday (ORCID: https://orcid.org/0000-0002-4362-461X)
- T R Price
- Chad Z. Tang (ORCID: https://orcid.org/0000-0002-5915-1327)
- Alexander D. Sherry (ORCID: https://orcid.org/0000-0001-5115-1691)
- Dan Zhao (ORCID: https://orcid.org/0000-0001-7066-9058)
- Brandon G. Smaglo (ORCID: https://orcid.org/0000-0002-8814-8004)
- Ethan B. Ludmir (ORCID: https://orcid.org/0000-0002-5472-5344)
- Eugene J. Koay (ORCID: https://orcid.org/0000-0001-7675-3461)
- Lorenzo Cohen (ORCID: https://orcid.org/0000-0003-4372-9208)
- Suyu Liu (ORCID: https://orcid.org/0000-0003-0126-2646)
- Robert A. Wolff (ORCID: https://orcid.org/0000-0002-6614-1610)
- Sonal S. Noticewala (ORCID: https://orcid.org/0000-0002-3153-0317)
- Cara Haymaker (ORCID: https://orcid.org/0000-0002-1317-9287)
- Sunyoung S. Lee (ORCID: https://orcid.org/0000-0002-5954-5991)
- Grace L. Smith (ORCID: https://orcid.org/0000-0002-3171-2911)
- Ryan W. Huey (ORCID: https://orcid.org/0000-0002-7887-8484)
- Jason A. Willis (ORCID: https://orcid.org/0000-0001-8238-8552)
- Marina Nayeli Medina-Rosales (ORCID: https://orcid.org/0000-0001-5174-8885)
- Albert C. Koong (ORCID: https://orcid.org/0000-0001-9824-1643)
- Cullen M. Taniguchi (ORCID: https://orcid.org/0000-0002-8052-3316)
- Bryan Fellman (ORCID: https://orcid.org/0000-0002-1810-5762)
- Tharakeswara Bathala (ORCID: https://orcid.org/0000-0001-8342-4519)
- Prajnan Das (ORCID: https://orcid.org/0000-0002-3845-0707)
- Shubham Pant (ORCID: https://orcid.org/0000-0001-9281-480X)
- Michael S. Lee (ORCID: https://orcid.org/0000-0001-8407-3423)
- Alexandre Reuben (ORCID: https://orcid.org/0000-0003-4510-0382)
- Sarah Nicholas
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Community Health Network (US)
- Banner MD Anderson Cancer Center
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1200/jco.24.00081
- Citations
- 49
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 13.84
Funders
- Cancer Prevention and Research Institute of Texas
- University of Texas MD Anderson Cancer Center
- National Cancer Institute