Trastuzumab Deruxtecan in Human Epidermal Growth Factor Receptor 2–Expressing Biliary Tract Cancer (HERB; NCCH1805): A Multicenter, Single-Arm, Phase II Trial
T-DXd showed promising activity in patients with HER2-positive BTC and a signal of efficacy in patients with HER2-low BTC. Although the safety profile was generally manageable, ILD requires careful monitoring and early intervention.
Authors
- Chigusa Morizane (ORCID: https://orcid.org/0000-0002-6560-7503)
- Ryo Sadachi (ORCID: https://orcid.org/0009-0009-9536-1506)
- Wataru Okamoto (ORCID: https://orcid.org/0000-0002-2602-7282)
- Yoshiaki Nakamura (ORCID: https://orcid.org/0000-0002-5241-6855)
- Masafumi Ikeda (ORCID: https://orcid.org/0000-0002-4050-2086)
- Yasuyuki Kawamoto (ORCID: https://orcid.org/0000-0002-7706-0015)
- Mitsuhito Sasaki (ORCID: https://orcid.org/0000-0002-3754-9027)
- Satoshi Kobayashi (ORCID: https://orcid.org/0000-0002-2535-6586)
- Aya Kuchiba (ORCID: https://orcid.org/0000-0002-6786-3527)
- Akihiro Ohba (ORCID: https://orcid.org/0000-0002-9153-3798)
- Makoto Ueno (ORCID: https://orcid.org/0000-0003-4480-0029)
- Nobuyoshi Hiraoka (ORCID: https://orcid.org/0000-0003-4215-4385)
- Yoshito Komatsu (ORCID: https://orcid.org/0000-0002-1570-6802)
- Hiroshi Yoshida (ORCID: https://orcid.org/0000-0002-7569-7813)
- Junji Furuse (ORCID: https://orcid.org/0000-0003-0663-6117)
- Naoko Matsui (ORCID: https://orcid.org/0009-0008-7902-3761)
- Takayuki Yoshino (ORCID: https://orcid.org/0000-0002-0489-4756)
- Naohiro Okano (ORCID: https://orcid.org/0000-0002-4098-5217)
- Takuji Okusaka (ORCID: https://orcid.org/0000-0003-1729-807X)
- Kenichi Nakamura (ORCID: https://orcid.org/0000-0003-3534-8296)
Institutions
- Kyorin University (JP)
- Kanagawa Prefectural Hospital Organization (JP)
- Hiroshima University Hospital (JP)
- Hokkaido University Hospital (JP)
- National Cancer Center Hospital East (JP)
- Tokyo National Hospital (JP)
- Kanagawa Cancer Center
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1200/jco.23.02010
- Citations
- 43
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 24.63
Funders
- Daiichi Sankyo Europe