Short-chain fatty acid butyrate against TMAO activating endoplasmic-reticulum stress and PERK/IRE1-axis with reducing atrial arrhythmia
TMAO administration led to PERK/IRE1α axis activation, which may increase atrial remodeling and arrhythmogenesis. SB treatment mitigated TMAO-elicited ER stress. This finding suggests that SB administration is a valuable strategy for treating TMAO-induced atrial arrhythmia.
Authors
- Satoshi Higa (ORCID: https://orcid.org/0000-0002-5735-6249)
- Ting-I Lee (ORCID: https://orcid.org/0000-0002-4883-0199)
- Pao‐Huan Chen (ORCID: https://orcid.org/0000-0001-8454-7414)
- Yao‐Chang Chen (ORCID: https://orcid.org/0000-0001-6589-6993)
- Tzu-Yu Cheng (ORCID: https://orcid.org/0000-0002-7887-2728)
- Yu‐Hsun Kao (ORCID: https://orcid.org/0000-0001-8687-5091)
- Shao‐Jung Li (ORCID: https://orcid.org/0000-0002-3608-6542)
- Ting-Wei Lee
Institutions
- Taipei Medical University Hospital (TW)
- Tomishiro Central Hospital (JP)
- Wan Fang Hospital (TW)
- Taipei Medical University (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1016/j.jare.2024.08.009
- Citations
- 18
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.21
Funders
- Okinawa Churashima Foundation
- Academia Sinica
- Taipei Medical University
- Advanced Research Center for Green Materials Science and Technology, National Taiwan University
- National Science and Technology Council
- Taipei Medical University Hospital
- Wan Fang Hospital