The reduction of LEDD leads to visual dysfunction in patients with PD after STN-DBS: a randomized clinical trial
Visual dysfunction, particularly a thinner RNFL and lower vessel density, is related to LEDD reduction after STN-DBS. Prolonged administration of dopamine-mimetic drugs prevents visual symptoms. Thus, physicians should consider LEDD adjustment when patients report visual dysfunction before surgery or severe visual symptoms after STN-DBS.
Authors
- Qianqian Wu (ORCID: https://orcid.org/0000-0002-8402-4055)
- Guangjian Zhang (ORCID: https://orcid.org/0000-0003-0888-5723)
- Chao Zhang (ORCID: https://orcid.org/0000-0001-8760-0110)
- Bin Huang (ORCID: https://orcid.org/0000-0002-5578-5082)
- Zhenke Li (ORCID: https://orcid.org/0009-0002-2746-8642)
- Ying Hou (ORCID: https://orcid.org/0000-0001-8116-4928)
- Weiguo Li (ORCID: https://orcid.org/0000-0001-8125-3824)
- Jinxing Sun (ORCID: https://orcid.org/0009-0001-7940-1653)
- Hong Wang (ORCID: https://orcid.org/0000-0002-4879-4482)
- Zhimin Zhao (ORCID: https://orcid.org/0000-0002-3384-2365)
- Xiangyu Ma (ORCID: https://orcid.org/0009-0001-1352-4968)
- Xingang Li (ORCID: https://orcid.org/0000-0002-4066-0973)
- Junheng Jia (ORCID: https://orcid.org/0009-0001-1404-1116)
- Shengmei Ma
- Qi Wang (ORCID: https://orcid.org/0000-0003-0962-4218)
Institutions
- Shandong University (CN)
- Weifang People's Hospital (CN)
- Shandong Provincial QianFoShan Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1097/js9.0000000000002018
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province