Pioneering an effect-based early warning system for hazardous chemicals in the environment
Existing regulatory frameworks often prove inadequate in identifying contaminants of emerging concern (CECs) and determining their impacts on biological systems at an early stage. The establishment of Early Warning Systems (EWSs) for CECs is becoming increasingly relevant for policy-making, aiming to proactively detect chemical hazards and implement effective mitigation measures. Effect-based methodologies, including bioassays and effect-directed analysis (EDA), offer valuable input to EWSs with a view to pinpointing the relevant toxicity drivers and prioritizing the associated risks. This review evaluates the analytical techniques currently available to assess biological effects, and provides a structured plan for their systematic integration into an EWS for hazardous chemicals in the environment. Key scientific advancements in effect-based approaches and EDA are discussed, underscoring their potential for early detection and management of chemical hazards. Additionally, critical challenges such as data integration and regulatory alignment are addressed, emphasizing the need for continuous improvement of the EWS and the incorporation of analytical advancements to safeguard environmental and public health from emerging chemical threats.
Authors
- Maria Larsson (ORCID: https://orcid.org/0000-0003-1404-3186)
- Mario Carere (ORCID: https://orcid.org/0000-0002-7611-9353)
- Valeria Dulio (ORCID: https://orcid.org/0000-0002-9436-9954)
- Katrin Vorkamp (ORCID: https://orcid.org/0000-0002-1131-5687)
- Tuulia Hyötyläinen (ORCID: https://orcid.org/0000-0002-1389-8302)
- Georgios Niarchos (ORCID: https://orcid.org/0000-0001-8318-1553)
- Johan Lundqvist (ORCID: https://orcid.org/0000-0001-5693-9007)
- Lutz Ahrens (ORCID: https://orcid.org/0000-0002-5430-6764)
- Nikiforos Alygizakis (ORCID: https://orcid.org/0000-0002-5727-4999)
- Paweł Rostkowski (ORCID: https://orcid.org/0000-0001-9778-4283)
- Anna Kärrman (ORCID: https://orcid.org/0000-0001-7555-142X)
- Roland Kallenborn (ORCID: https://orcid.org/0000-0003-1703-2538)
- Dimosthenis Sarigiannis (ORCID: https://orcid.org/0000-0003-2514-314X)
- Laura Mancini (ORCID: https://orcid.org/0000-0003-3667-5221)
- M.H. Lamoree (ORCID: https://orcid.org/0000-0002-7373-7738)
- Javad Mottaghipisheh
- Achilleas Karakoltzidis
- Spyros Karakitsios
- Magnus Engwall
Institutions
- National and Kapodistrian University of Athens (GR)
- Aarhus University (DK)
- Aristotle University of Thessaloniki (GR)
- Örebro University (SE)
- Istituto Superiore di Sanità (IT)
- Swedish University of Agricultural Sciences (SE)
- Institut national de l'environnement industriel et des risques (FR)
- Norwegian University of Life Sciences (NO)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- TrAC Trends in Analytical Chemistry
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1016/j.trac.2024.117901
- Citations
- 8
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 2.52
Funders
- European Commission
- HORIZON EUROPE Framework Programme