Interplay of Large Neutral Amino Acids, Metabolic Syndrome, and Apolipoprotein E ε4 on Brain Integrity at Midlife
The study highlights significant 3-way interactions between LNAA, MetS, and genetic risk factors in the pathology of WMH, particularly in individuals genetically predisposed to Alzheimer's disease. These interactions suggest differential impacts of LNAA on WMH volume dependent on both genetic and metabolic factors. Results emphasize the need for personalized metabolic and genetic profile assessments in neurodegenerative disease management.
Authors
- Cherry Youn (ORCID: https://orcid.org/0000-0001-5445-6802)
- Barbara Strasser (ORCID: https://orcid.org/0000-0002-4318-5629)
- Hirofumi Tanaka (ORCID: https://orcid.org/0000-0002-1780-7471)
- Marie Caillaud (ORCID: https://orcid.org/0000-0002-6977-8182)
- Isabelle Gallagher (ORCID: https://orcid.org/0000-0003-1686-2134)
- Andreana P. Haley (ORCID: https://orcid.org/0000-0003-1861-7861)
- Yanrong Li (ORCID: https://orcid.org/0000-0002-0206-3473)
Institutions
- Sigmund Freud Privatuniversität Wien (AT)
- Ludwig Boltzmann Institute for Cancer Research (AT)
- Ludwig Boltzmann Institute for Digital Health and Prevention (AT)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Lifestyle Genomics
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1159/000540336
- Citations
- 3
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.98
Funders
- National Institutes of Health