Clinical Impact of Lipoprotein (a) and Cumulative Low-Density Lipoprotein Cholesterol Exposure on Coronary Artery Disease in Patients with Heterozygous Familial Hypercholesterolemia
This study demonstrated an additive effect of Lp(a) and cumulative LDL-C exposure on CAD in patients with HeFH. Interaction with traditional risk factors, particularly smoking and cumulative LDL-C exposure, enormously enhances the cardiovascular risk in this population.
Authors
- Mariko Harada‐Shiba (ORCID: https://orcid.org/0000-0002-7600-2059)
- Masaaki Hoshiga
- Shimpei Fujioka (ORCID: https://orcid.org/0000-0002-1132-3564)
- Hideaki Morita (ORCID: https://orcid.org/0000-0003-0928-8322)
- Daisuke Shishikura (ORCID: https://orcid.org/0000-0002-5440-2051)
- Yumiko Kanzaki (ORCID: https://orcid.org/0000-0003-1228-1201)
- Masahito Michikura (ORCID: https://orcid.org/0000-0002-1258-8310)
- Tomohiro Fujisaka
Institutions
- Osaka University of Pharmaceutical Sciences (JP)
Publication Details
- Journal
- Journal of Atherosclerosis and Thrombosis
- Published
- 2024-08-05
- DOI
- https://doi.org/10.5551/jat.65009
- Citations
- 4
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 2.29