Association of glucagon-like peptide-1 receptor agonists with suicidal ideation and self-injury in individuals with diabetes and obesity: a propensity-weighted, population-based cohort study
Our findings do not support an increased risk of SIS when taking GLP-1RA in individuals with type 2 diabetes and obesity; however, the rarity of SIS events and the wide uncertainty of effect size (although null, effect may be compatible with a risk as high as threefold) calls for a cautious interpretation of our results. Further studies, including final evaluations from regulatory bodies, are called for to discard a causal link between GLP-1RA and suicidality.
Authors
- Aníbal García‐Sempere (ORCID: https://orcid.org/0000-0002-4313-3976)
- Salvador Peiró (ORCID: https://orcid.org/0000-0002-3902-569X)
- Isabel Hurtado (ORCID: https://orcid.org/0000-0002-8475-8112)
- Gabriel Sanfélix‐Gimeno (ORCID: https://orcid.org/0000-0001-7098-4576)
- Celia Robles (ORCID: https://orcid.org/0000-0002-3978-7336)
Institutions
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (ES)
- Red de Investigación en Actividades Preventivas y Promoción de la Salud (ES)
Publication Details
- Journal
- Diabetologia
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1007/s00125-024-06243-z
- Citations
- 34
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 12.16