Identifying and validating the roles of the cuproptosis-related gene DKC1 in cancer with a focus on esophageal carcinoma
In this study, we conducted a systematic analysis of DKC1 and its regulatory factors and experimentally validated its excellent diagnostic and prognostic abilities in various cancers. Further research indicated that DKC1 may reshape the tumor microenvironment (TME), highlighting the potential of DKC1-based cancer treatment and its usefulness in predicting the response to chemotherapy.
Authors
- Xu‐Feng Huang (ORCID: https://orcid.org/0000-0002-5895-2253)
- Qingwen Zhu (ORCID: https://orcid.org/0000-0002-5298-5361)
- Bohao Zhang (ORCID: https://orcid.org/0000-0002-0485-3735)
- Yanru Qin
- D D Zhang (ORCID: https://orcid.org/0000-0002-2519-8354)
- Jiaxin Zhang (ORCID: https://orcid.org/0000-0001-8585-9006)
Institutions
- University of Debrecen (HU)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1007/s00432-024-05870-8
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China
- Henan Provincial Science and Technology Research Project