Whole-exome and whole-genome sequencing of 1064 individuals with type 1 diabetes reveals novel genes for diabetic kidney disease
Our sequencing-based meta-analysis revealed multiple genes, variants and regulatory regions that were suggestively associated with DKD. However, as no variant or gene reached genome-wide significance, further studies are needed to validate the findings.
Authors
- Bridget M. Lin (ORCID: https://orcid.org/0000-0002-5313-4171)
- Per‐Henrik Groop (ORCID: https://orcid.org/0000-0003-4055-6954)
- Erkka Valo (ORCID: https://orcid.org/0000-0003-0672-554X)
- Anna Syreeni (ORCID: https://orcid.org/0000-0003-1857-2560)
- Jani K. Haukka (ORCID: https://orcid.org/0000-0001-5663-0923)
- Anni A. Antikainen (ORCID: https://orcid.org/0000-0003-2488-6830)
- Emma H. Dahlström (ORCID: https://orcid.org/0000-0003-1271-8696)
- Niina Sandholm (ORCID: https://orcid.org/0000-0003-4322-6942)
- Valma Harjutsalo (ORCID: https://orcid.org/0000-0003-3568-9779)
- Andrzej S. Królewski (ORCID: https://orcid.org/0000-0002-1705-2953)
- Nora Franceschini
Institutions
- University of North Carolina at Chapel Hill (US)
- Joslin Diabetes Center (US)
- University of Helsinki (FI)
- Harvard University (US)
- Helsinki University Hospital (FI)
- Institute for Molecular Medicine Finland (FI)
- Folkhälsans Forskningscentrum (FI)
- Monash University (AU)
Publication Details
- Journal
- Diabetologia
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1007/s00125-024-06241-1
- Citations
- 4
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- Helsingin Yliopisto
- Helsingin ja Uudenmaan Sairaanhoitopiiri
- Wilhelm och Else Stockmanns Stiftelse
- Folkhälsanin Tutkimussäätiö
- Munuaissäätiö
- Academy of Finland
- Novo Nordisk
- China Scholarship Council
- Samfundet Folkhälsan
- Sigrid Juséliuksen Säätiö
- Novo Nordisk Fonden
- Diabetestutkimussäätiö