Efficiency of acetate-based isopropanol synthesis in Escherichia coli W is controlled by ATP demand
Using the newly gained system-level understanding for isopropanol production from acetate, we assessed possible engineering approaches and propose process designs to maximize production. Collectively, our work contributes to the establishment and optimization of acetate-based bioproduction systems.
Authors
- Ruth Birner‐Gruenberger (ORCID: https://orcid.org/0000-0003-3950-0312)
- Regina Kutscha (ORCID: https://orcid.org/0000-0002-6720-7634)
- Pavlos Stephanos Bekiaris (ORCID: https://orcid.org/0000-0002-3047-4253)
- Stefan Pflügl (ORCID: https://orcid.org/0000-0001-8472-5073)
- Steffen Klamt (ORCID: https://orcid.org/0000-0003-2563-7561)
- Tamara Tomin (ORCID: https://orcid.org/0000-0002-7071-2316)
Institutions
- TU Wien (AT)
- Max Planck Institute for Dynamics of Complex Technical Systems (DE)
Publication Details
- Journal
- Biotechnology for Biofuels and Bioproducts
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1186/s13068-024-02534-0
- Citations
- 3
- Primary Topic
- Microbial Metabolic Engineering and Bioproduction
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Technische Universität Wien
- Österreichische Forschungsförderungsgesellschaft
- Technische Universität Wien Bibliothek