Direct Multicomponent Synthesis of C3-Arylated Pyrroles under Catalyst-Free Conditions
Abstract An operationally simple catalyst-free protocol for the direct regiospecific synthesis of C3-arylated/alkenylated pyrroles has been developed. The enamine-intermediate, in situ generated from succinaldehyde and a primary amine, was trapped with activated carbonyls before the Paal–Knorr reaction in a direct multicomponent ‘just-mix’ protocol to furnish pyrroles in good yields. Several C3-substituted N-alkylpyrroles have been prepared under open-flask conditions, avoiding protection-deprotection chemistry.
Authors
- Atul Jankiram Dolas
- Eldhose Iype (ORCID: https://orcid.org/0000-0003-4451-2668)
- Yadav Kacharu Nagare (ORCID: https://orcid.org/0000-0002-2752-7457)
- Amol Prakash Pawar (ORCID: https://orcid.org/0000-0003-4516-0916)
- Krishnan Rangan (ORCID: https://orcid.org/0000-0002-0518-8431)
- Indresh Kumar (ORCID: https://orcid.org/0000-0003-4621-1236)
- Reena Jangir
Institutions
- American University of the Middle East (KW)
- Birla Institute of Technology and Science - Hyderabad Campus (IN)
- Birla Institute of Technology and Science, Pilani - Goa Campus (IN)
- AAA College of Engineering and Technology
- Birla Institute of Technology and Science, Pilani (IN)
Publication Details
- Journal
- Synthesis
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1055/a-2380-3855
- Primary Topic
- Synthesis and Characterization of Pyrroles
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Engineering Research Board