Calciprotein particle counts associate with vascular remodelling in chronic kidney disease
Our findings reveal that CKD is characterized by systemic VC with increased calcification propensity and CPP counts. Transcriptome profiling showed altered vascular gene expression with enrichment for endothelial activation, inflammation, ECM remodelling, and ossification. Moreover, we demonstrate, for the first time, that vascular remodelling processes are associated with increased circulating CPP counts. Interventions targeting CPPs are promising avenues for alleviating vascular remodelling and VC in CKD.
Authors
- Riemer H. J. A. Slart (ORCID: https://orcid.org/0000-0002-5565-1164)
- Adee Bodewes (ORCID: https://orcid.org/0000-0002-9029-5396)
- António W. Gomes‐Neto (ORCID: https://orcid.org/0000-0002-4398-4877)
- C. Tji Gan (ORCID: https://orcid.org/0000-0002-1310-4189)
- Hubert G.M. Niesters (ORCID: https://orcid.org/0000-0002-1758-0430)
- Hans Blokzijl (ORCID: https://orcid.org/0000-0003-4240-7506)
- Marius C. van den Heuvel (ORCID: https://orcid.org/0000-0001-6985-7107)
- Andreas Pasch (ORCID: https://orcid.org/0000-0002-7439-0748)
- Marcel J. W. Greuter (ORCID: https://orcid.org/0000-0001-5721-9159)
- Guido Krenning (ORCID: https://orcid.org/0000-0001-5850-5667)
- Coretta van Leer‐Buter (ORCID: https://orcid.org/0000-0002-4072-7373)
- Eelko Hak (ORCID: https://orcid.org/0000-0003-0849-7210)
- Rianne M. Douwes (ORCID: https://orcid.org/0000-0002-2517-5769)
- Frank Klont (ORCID: https://orcid.org/0000-0003-3503-1694)
- Monique E. Lodewijk
- Vincent E. de Meijer (ORCID: https://orcid.org/0000-0002-7900-5917)
- Robert A. Pol (ORCID: https://orcid.org/0000-0002-2236-5233)
- Kevin Damman (ORCID: https://orcid.org/0000-0003-0190-2228)
- Michiel E. Erasmus (ORCID: https://orcid.org/0000-0002-6234-2976)
- Lian Feenstra (ORCID: https://orcid.org/0000-0003-1297-5887)
- Charlotte A. te Velde‐Keyzer (ORCID: https://orcid.org/0000-0002-8197-8056)
- Jan‐Stephan Sanders (ORCID: https://orcid.org/0000-0002-0904-3969)
- Riemer J H J A Slart
- Caecilia S E Doorenbos (ORCID: https://orcid.org/0000-0001-8036-520X)
- Melanie Reijrink (ORCID: https://orcid.org/0000-0001-9447-7333)
- Michel J. Vos (ORCID: https://orcid.org/0000-0001-9379-2219)
- Gerard D. H. Dijkstra (ORCID: https://orcid.org/0000-0003-4563-7462)
- Rinse Karel Weersma (ORCID: https://orcid.org/0000-0001-7928-7371)
- Marco van Londen (ORCID: https://orcid.org/0000-0001-7145-3240)
- Douwe J. Mulder (ORCID: https://orcid.org/0000-0003-3715-6474)
- Marion J. Siebelink (ORCID: https://orcid.org/0000-0001-5366-1732)
- Willem S. Lexmond
- Edward R. Smith (ORCID: https://orcid.org/0000-0002-2651-1787)
- Arjan Diepstra (ORCID: https://orcid.org/0000-0001-9239-1050)
- Jan‐Luuk Hillebrands (ORCID: https://orcid.org/0000-0003-3135-3274)
- L. Joost van Pelt (ORCID: https://orcid.org/0000-0001-5538-1806)
- V Adelita Ranchor
- G Bouke Hepkema
- A M Erik Verschuuren
- J Gertrude Nieuwenhuis-Moeke
- G D Henri Leuvenink
- Robert J Porte
- J Daan Touw
- Marian Bulthuis
- Mirjam F. Mastik
- J Cas Swarte
- Marieke T. de Boer (ORCID: https://orcid.org/0009-0008-0634-4740)
- Lotte M Visser
Institutions
- Johannes Kepler University of Linz (AT)
- The Royal Melbourne Hospital (AU)
- University Medical Center Groningen (NL)
- The University of Melbourne (AU)
- University of Groningen (NL)
- Horizon College and Seminary (CA)
- University of Twente (NL)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1093/cvr/cvae164
- Citations
- 12
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.07
Funders
- Sylvia and Charles Viertel Charitable Foundation
- Stichting De Cock-Hadders
- Amsterdam University Medical Centers
- Rijksuniversiteit Groningen
- Nierstichting
- Astellas Pharma
- Universitair Medisch Centrum Groningen
- Astellas Pharma Europe