Slack K+ channels confer protection against myocardial ischaemia/reperfusion injury
Collectively, our study provides evidence for Slack's crucial involvement in the ion homeostasis of no or low O2-stressed CMs. Thereby, Slack activity opposes the I/R-induced fatal Ca2+-uptake to CMs supporting the cardioprotective signaling attributed to mitoKATP function.
Authors
- David Skrabak
- Lucas Matt (ORCID: https://orcid.org/0000-0003-3235-5140)
- Achim Schmidtko (ORCID: https://orcid.org/0000-0001-7270-5075)
- Melanie Cruz Santos
- Robert Łukowski (ORCID: https://orcid.org/0000-0002-4564-3574)
- Rebekka Ehinger
- Nadja I. Bork
- Roland Malli (ORCID: https://orcid.org/0000-0001-6327-8729)
- Viacheslav O. Nikolaev (ORCID: https://orcid.org/0000-0002-7529-5179)
- Sandra Burgstaller (ORCID: https://orcid.org/0000-0002-3926-7023)
- Meinrad Gawaz (ORCID: https://orcid.org/0000-0003-1124-9592)
- Natalie Längst
- Helmut Bischof (ORCID: https://orcid.org/0000-0003-2380-600X)
- Anna Roslan
- Jiaqi Yang (ORCID: https://orcid.org/0000-0003-4431-9657)
- Peter Ruth (ORCID: https://orcid.org/0000-0002-1092-857X)
- Katharina Paulus
- Annika Luczak
- Sophia Schanz
Institutions
- Goethe University Frankfurt (DE)
- Universität Hamburg (DE)
- Medical University of Graz (AT)
- University Medical Center Hamburg-Eppendorf (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1093/cvr/cvae155
- Citations
- 6
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 2.55
Funders
- Deutsche Forschungsgemeinschaft
- China Scholarship Council