Distinct Patterns of Brain Atrophy in Amnestic Mild Cognitive Impairment and Motoric Cognitive Risk Syndromes
Distinct patterns of atrophy were associated with MCR and aMCI. A distributed pattern of cortical atrophy - that is more consistent with VaD or mixed dementia- was observed in MCR. A more restricted pattern of atrophy - that is more consistent with AD - was observed in aMCI. The biological underpinnings of MCR and aMCI likely differ and may require tailored interventions.
Authors
- Richard B. Lipton (ORCID: https://orcid.org/0000-0003-2652-2897)
- Hiroyuki Shimada
- Nir Barzilai (ORCID: https://orcid.org/0000-0002-7787-6268)
- Joe Verghese (ORCID: https://orcid.org/0000-0003-4252-2547)
- Emmeline Ayers (ORCID: https://orcid.org/0000-0002-5061-3708)
- Helena M. Blumen (ORCID: https://orcid.org/0000-0002-0275-6616)
- Velandai Srikanth (ORCID: https://orcid.org/0000-0002-8442-8981)
- Vineela Nagamalla
- Olivier Beauchet
Institutions
- Albert Einstein College of Medicine (US)
- National Ageing Research Institute (AU)
- Peninsula Health (AU)
- National Center for Geriatrics and Gerontology (JP)
- Monash University (AU)
Publication Details
- Journal
- Neurodegenerative Diseases
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1159/000540512
- Citations
- 5
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.93