Variants of human DECTIN-1 rs16910526 are linked to differential reactive oxygen species production and susceptibility to tuberculosis
Our study identified a significant association between the SNP variant rs16910526 in the DECTIN-1 gene and Dectin-1 expression in the PMN, leading to altered ROS production. The higher frequency of this variant in TB patients compared to HS suggests a possible link with susceptibility to TB disease in Argentina.
Authors
- Mercedes Alemán (ORCID: https://orcid.org/0000-0001-6215-1435)
- Domingo Palmero (ORCID: https://orcid.org/0000-0002-7496-5492)
- Rodrigo Failde
- M Pastorini
- Mónica Cufré
- Ignacio Martín (ORCID: https://orcid.org/0000-0002-5862-513X)
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Hospital Muñiz (AR)
- Experimental Medicine and Biology Institute (AR)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1186/s12929-024-01067-w
- Citations
- 1
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Fundación Alberto J. Roemmers