Fluoride induces hepatointestinal damage and vitamin B2 mitigation by regulating IL-17A and Bifidobacterium in ileum
Fluoride induces morphological and functional impairment of liver and gut tissues, as well as enterohepatic circulation disorder by altering total bile acid (TBA) synthesis, transporters, and FXR-FGF15 signaling regulation. Vitamin B2 attenuated fluoride-induced enterohepatic circulation disorder through IL-17A knockout and ileal microbiome regulation. The ileum was found to be the most sensitive to fluoride, leading to changes in ileal microbiome, particularly the reduction of Bifidobacterium. Furthermore, Bifidobacterium supplementation reversed fluoride-induced hepatointestinal injury. This study not only elucidates a novel mechanism by which fluoride causes hepatointestinal toxicity, but also provides a new physiological function of vitamin B<sub>2</sub>, which will be useful in the therapy of fluorosis and other hepatoenterological diseases.
Authors
- Weixiang Fu
- Yangfei Zhao (ORCID: https://orcid.org/0000-0002-8375-5091)
- Bohui Li (ORCID: https://orcid.org/0000-0002-5212-334X)
- Ram Kumar Manthari (ORCID: https://orcid.org/0000-0002-1294-9788)
- Jianhai Zhang (ORCID: https://orcid.org/0000-0001-6005-8376)
- Yanjia Tan
- Chenkai Cheng
- Cuicui Zhuang (ORCID: https://orcid.org/0000-0002-1575-6156)
- Liang Chen (ORCID: https://orcid.org/0000-0002-2819-8288)
- Jundong Wang (ORCID: https://orcid.org/0000-0002-1704-7724)
- Xiang Li (ORCID: https://orcid.org/0000-0003-2964-8639)
- Yue Wu (ORCID: https://orcid.org/0009-0007-2910-8049)
- Jie Yang (ORCID: https://orcid.org/0000-0002-8648-4119)
- Jia‐Wei Lv (ORCID: https://orcid.org/0000-0001-9278-0929)
- Qianlong Zhu
- Jian Bai
Institutions
- Shanxi Agricultural University (CN)
- GITAM University (IN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1016/j.jare.2024.07.034
- Citations
- 6
- Primary Topic
- Fluoride Effects and Removal
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- National Natural Science Foundation of China
- Shanxi Scholarship Council of China
- Earmarked Fund for Modern Agro-industry Technology Research System