Bioinformatics study of the TNFRSF1A mechanism involved in acute liver injury in sepsis through the mTOR signaling pathway.
The key genes identified and related signaling pathways provided insights into the molecular mechanisms of sepsis-induced acute liver injury. In vivo studies revealed the overexpression of <i>CXCL1, ICAM1</i>, and <i>TNFRSF1A</i> mRNA in sepsis-mediated injured liver tissues, providing a theoretical basis for early diagnosis and targeted treatment research.
Authors
- Kankai Tang
- Zhidong Chen (ORCID: https://orcid.org/0000-0002-9383-9563)
- Zhang Hui (ORCID: https://orcid.org/0000-0002-0084-6538)
Institutions
- Huzhou Normal University (CN)
- Third People's Hospital of Huzhou (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-03-01
- DOI
- https://doi.org/10.14670/hh-18-789
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35