Bile Acid Injection Regulated Blood Glucose in T2DM Rats Via the TGR5/GLP-1 Rather than FXR/FGF15 Pathway.
Bile acids treatment promotes glucose homeostasis in the STZ-induced T2MD rat model via the following mechanism by activating the TGR5/GLP-1 signaling pathway rather than FXR/FGF15 pathway to improve glucose tolerance and thus achieve glucose homeostasis. The bile acid/TGR5/GLP-1 signaling pathway may be a crucial mechanism of controlling the blood glucose of T2DM rats, and TGR5/GLP-1 pathway may constitute novel targets for treating T2DM.
Authors
- Siqi Xie (ORCID: https://orcid.org/0000-0002-8163-1167)
- Bin Zhang (ORCID: https://orcid.org/0000-0002-4371-4746)
- Zhen Chen (ORCID: https://orcid.org/0000-0003-3949-5744)
- Xing Zhu
- Mingchang Wang
Publication Details
- Journal
- PubMed
- Published
- 2024-12-01
- Citations
- 3
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.70