Analyzing heterogeneity in Alzheimer disease using multimodal normative modeling on imaging‐based ATN biomarkers
Normative modeling examined AD heterogeneity across multimodal imaging biomarkers. Heterogeneity in spatial patterns of gray matter atrophy, amyloid, and tau burden. Higher within-group heterogeneity for AD patients at advanced dementia stages. Patient-specific metric summarized extent of neurodegeneration and neuropathology. Metric is a marker of poor brain health and can monitor risk of disease progression.
Authors
- Tammie L.S. Benzinger (ORCID: https://orcid.org/0000-0002-8114-0552)
- Aristeidis Sotiras (ORCID: https://orcid.org/0000-0003-0795-8820)
- Tom Earnest (ORCID: https://orcid.org/0000-0001-8671-8424)
- Deydeep Kothapalli
- Jason J. Hassenstab (ORCID: https://orcid.org/0000-0002-7802-3371)
- John C. Morris (ORCID: https://orcid.org/0000-0001-9820-5618)
- Braden Yang (ORCID: https://orcid.org/0000-0002-2558-4132)
- Philip Payne (ORCID: https://orcid.org/0000-0002-9532-2998)
- Beau M. Ances (ORCID: https://orcid.org/0000-0003-3862-7397)
- Andrew J. Aschenbrenner (ORCID: https://orcid.org/0000-0002-4317-7282)
- Brian A. Gordon (ORCID: https://orcid.org/0000-0003-2109-2955)
- Sayantan Kumar (ORCID: https://orcid.org/0000-0001-7213-0734)
- Chengie Xiong (ORCID: https://orcid.org/0009-0001-0289-148X)
Institutions
- Washington University in St. Louis (US)
- Mallinckrodt (United States) (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/alz.70143
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Institutes of Health
- McDonnell Center for Systems Neuroscience
- National Institute on Aging