GlucOS: Security, correctness, and simplicity for automated insulin delivery

We present GlucOS, a novel system for trustworthy automated insulin delivery. Fundamentally, this paper is about a system we designed, implemented, and deployed on real humans and the lessons learned from our experiences. GlucOS introduces a novel architecture that allows users to personalize diabetes management using any predictive model (including ML) for insulin dosing while simultaneously protecting them against malicious models. We also introduce a novel holistic security mechanism that adapts to unprecedented changes to human physiology. We use formal methods to prove correctness of critical components and incorporate humans as part of our defensive strategy. Our evaluation includes both a real-world deployment with seven individuals and results from simulation to show that our techniques generalize. We highlight that our results are not from a lab study, with people using GlucOS to manage Type 1 Diabetes in their daily lives. Our results show that GlucOS maintains safety and improves glucose control even under attack conditions. This work demonstrates the potential for secure, personalized, automated healthcare systems. Our entire source code is available at this link.

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Publication Details

Published
2026-05-29
DOI
https://doi.org/10.1145/3745756.3809198
Primary Topic
Diabetes Management and Research
Type
preprint
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preprint

GlucOS: Security, correctness, and simplicity for automated insulin delivery

Stephanie S. Crossen, Hari Venugopalan, Shreyas Madhav Ambattur Vijayanand, Caleb Stanford et al.
Diabetes Management and Research
preprint

GlucOS: Security, correctness, and simplicity for automated insulin delivery

Stephanie S. Crossen, Hari Venugopalan, Shreyas Madhav Ambattur Vijayanand, Caleb Stanford, Samuel T. King
preprint en

Abstract

We present GlucOS, a novel system for trustworthy automated insulin delivery. Fundamentally, this paper is about a system we designed, implemented, and deployed on real humans and the lessons learned from our experiences. GlucOS introduces a novel architecture that allows users to personalize diabetes management using any predictive model (including ML) for insulin dosing while simultaneously protecting them against malicious models. We also introduce a novel holistic security mechanism that adapts to unprecedented changes to human physiology. We use formal methods to prove correctness of critical components and incorporate humans as part of our defensive strategy. Our evaluation includes both a real-world deployment with seven individuals and results from simulation to show that our techniques generalize. We highlight that our results are not from a lab study, with people using GlucOS to manage Type 1 Diabetes in their daily lives. Our results show that GlucOS maintains safety and improves glucose control even under attack conditions. This work demonstrates the potential for secure, personalized, automated healthcare systems. Our entire source code is available at this link.

University of California, Davis (US)
Openalex Percentile: Top 100%
Diabetes Management and Research
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