The temporal relationship between body composition and cardiometabolic profiles in an HIV-infected (on antiretroviral therapy) versus HIV-free Western Cape study population

Cardiovascular risk is a health concern in people living with HIV/AIDS (PLWH). This longitudinal study (baseline vs 36 months) aimed to investigate the relationship between body composition and markers of cardiovascular risk in a South African study population [HIV free, <i>n</i> = 22 vs HIV positive on antiretroviral therapy (HIV+ART), <i>n</i> = 73)]. Health questionnaires, anthropometric measurements, biochemical analyses and flow-mediated dilation were performed. Linear mixed-model statistical analyses were applied. The HIV+ART vs the HIV-free groups were independently associated with body mass index (BMI) [-4.92 (-7.99 to -1.84), <i>p</i> = 0.002] and waist circumference [-10.5 (-17.2 to -3.77), <i>p</i> = 0.003]. ART duration was associated with BMI [2.60 (0.57-4.62), <i>p</i> = 0.013], waist circumference [3.83 (0.03-7.63), <i>p</i> = 0.048] and high-density lipoprotein cholesterol [20.18 (2.37-41.09), <i>p</i> = 0.025]. The data showed that intricate relationships existed in this study population between HIV, ART, body composition and cardiometabolic variables. There is a need for more research investigating cardiovascular risk in PLWH, particularly in the context of changes in body composition measures.