Clavulanic Acid Decreases Cocaine Cue Reactivity in Addiction-Related Brain Areas, a Randomized fMRI Pilot Study
CLAV reduced the response of the brain regions associated with motivation and emotional response during the DOWN condition compared to PBO, suggesting CLAV may strengthen voluntary efforts to avoid cocaine use. This pilot data supports the use of CLAV for CUD. (Trial registered in ClinicalTrials.gov NCT04411914).
Authors
- Mary F. Morrison (ORCID: https://orcid.org/0000-0002-9114-2295)
- Daohai Yu (ORCID: https://orcid.org/0000-0003-1034-3130)
- Helene L. Philogene-Khalid (ORCID: https://orcid.org/0000-0003-1466-7685)
- Xiaoning Lu (ORCID: https://orcid.org/0000-0002-9544-7395)
- Kanchana Jagannathan (ORCID: https://orcid.org/0000-0002-8314-0898)
- Linda S Callans
- Mark Walters
- Ronan Cunningham
Institutions
- Jagannath University (IN)
- Temple University Health System (US)
- King Khalid University (SA)
- Temple University (US)
Publication Details
- Journal
- Psychopharmacology Bulletin
- Published
- 2025-08-12
- DOI
- https://doi.org/10.64719/pb.4485
- Citations
- 2
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Institutes of Health