Singular limit of a chemotaxis model with indirect signal production and phenotype switching

Abstract Convergence of solutions to a partially diffusive chemotaxis system with indirect signal production and phenotype switching is shown in a two-dimensional setting when the switching rate increases to infinity, thereby providing a rigorous justification of formal computations performed in the literature. The expected limit system being the classical parabolic–parabolic Keller–Segel system, the obtained convergence is restricted to a finite time interval for general initial conditions but valid for arbitrary bounded time intervals when the mass of the initial condition is appropriately small. Furthermore, if the solution to the limit system blows up in finite time, then neither of the two phenotypes in the partially diffusive system can be uniformly bounded with respect to the L 2 -norm beyond that time.

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Publication Details

Journal
Nonlinearity
Published
2024-09-03
DOI
https://doi.org/10.1088/1361-6544/ad6bdf
Citations
5
Primary Topic
Mathematical Biology Tumor Growth
Type
article
Field-Weighted Citation Impact
1.98
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article

Singular limit of a chemotaxis model with indirect signal production and phenotype switching

Philippe Laurençot, Christian Stinner
5 citations
Nonlinearity
Mathematical Biology Tumor Growth
1.98
article

Singular limit of a chemotaxis model with indirect signal production and phenotype switching

Philippe Laurençot, Christian Stinner
article en
5 citations

Abstract

Abstract Convergence of solutions to a partially diffusive chemotaxis system with indirect signal production and phenotype switching is shown in a two-dimensional setting when the switching rate increases to infinity, thereby providing a rigorous justification of formal computations performed in the literature. The expected limit system being the classical parabolic–parabolic Keller–Segel system, the obtained convergence is restricted to a finite time interval for general initial conditions but valid for arbitrary bounded time intervals when the mass of the initial condition is appropriately small. Furthermore, if the solution to the limit system blows up in finite time, then neither of the two phenotypes in the partially diffusive system can be uniformly bounded with respect to the L 2 -norm beyond that time.

NonlinearityVol. 37(10)
Darmstadt University of Applied Sciences (DE), Laboratoire d’Analyse et de Mathématiques Appliquées (FR), Laboratoire de Mathématiques Blaise Pascal (FR), Université Savoie Mont Blanc (FR)
Openalex Percentile: Top 16%
Mathematical Biology Tumor Growth
1.98
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