Rare Variants Associated With Pediatric Cancer Treatment–Related Second Malignant Neoplasm Risk
This study provides new evidence regarding the involvement of genetics in the development of SMN. Additional research is needed to confirm these results and uncover the underlying mechanisms behind these associations. If replicated, these findings will help identify survivors at higher risk of developing SMN, enabling tailored treatment and follow-up strategies.
Authors
- Franck Bourdeaut (ORCID: https://orcid.org/0000-0001-9489-6781)
- Filippo Rosselli (ORCID: https://orcid.org/0000-0003-1080-5745)
- Hélène Blanché (ORCID: https://orcid.org/0000-0003-2115-575X)
- Julie Nys
- Brice Fresneau (ORCID: https://orcid.org/0000-0001-7603-7828)
- Robert Olaso (ORCID: https://orcid.org/0000-0001-7631-9657)
- Giao Vu‐Bezin (ORCID: https://orcid.org/0000-0002-9553-0527)
- Nadia Haddy (ORCID: https://orcid.org/0000-0001-9316-8280)
- Boris Schwartz (ORCID: https://orcid.org/0000-0003-1074-7266)
- Florent de Vathaire (ORCID: https://orcid.org/0000-0002-8374-9281)
- Rodrigue S. Allodji (ORCID: https://orcid.org/0000-0002-1895-8415)
- Ibrahima Diallo (ORCID: https://orcid.org/0000-0002-8272-8817)
- Anne Boland (ORCID: https://orcid.org/0000-0001-8789-5676)
- Sarah Winter (ORCID: https://orcid.org/0000-0002-5227-3890)
- Thomas Ludwig (ORCID: https://orcid.org/0000-0002-9996-1084)
- Chiraz El‐Fayech (ORCID: https://orcid.org/0000-0002-0309-9988)
- Gaëlle Marenne (ORCID: https://orcid.org/0000-0002-4363-7170)
- Simone Benhamou (ORCID: https://orcid.org/0000-0003-1162-9165)
- Claire Ducos (ORCID: https://orcid.org/0000-0001-9485-8056)
- Carolé Rubino
- Jean‐François Deleuze
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Bretagne Occidentale (FR)
- École nationale d'ingénieurs de Brest (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Fondation Jean Dausset-CEPH (FR)
- Centre National de Recherche en Génomique Humaine (FR)
- La Ligue Contre le Cancer (FR)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- CEA Paris-Saclay (FR)
- Centre Hospitalier Régional Universitaire de Brest (FR)
- Institut Curie (FR)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1200/po-24-00668
- Primary Topic
- Childhood Cancer Survivors' Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 0.00