Asymptotic online FWER control for dependent test statistics

In online multiple testing, an a priori unknown number of hypotheses are tested sequentially, that is, at each time point, a test decision for the current hypothesis has to be made using only the data available so far. Although many powerful test procedures have been developed for online error control in recent years, most of them are designed solely for independent or at most locally dependent test statistics. In this work, we provide a new framework for deriving online multiple test procedures that ensure asymptotical (with respect to the sample size) control of the familywise error rate, regardless of the dependence structure between test statistics. In this context, we give a few concrete examples of such test procedures and discuss their properties. Furthermore, we conduct a simulation study in which the type I error control of these test procedures is also confirmed for a finite sample size, and a gain in power is indicated.

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Publication Details

Journal
Statistical Methods in Medical Research
Published
2026-07-02
DOI
https://doi.org/10.1177/09622802261461776
Primary Topic
Statistical Methods in Clinical Trials
Type
preprint
Field-Weighted Citation Impact
0.00

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preprint

Asymptotic online FWER control for dependent test statistics

Werner Brannath, Lasse Fischer, V. Jankovic
Statistical Methods in Medical Research
Statistical Methods in Clinical Trials
preprint

Asymptotic online FWER control for dependent test statistics

Werner Brannath, Lasse Fischer, V. Jankovic
preprint en

Abstract

In online multiple testing, an a priori unknown number of hypotheses are tested sequentially, that is, at each time point, a test decision for the current hypothesis has to be made using only the data available so far. Although many powerful test procedures have been developed for online error control in recent years, most of them are designed solely for independent or at most locally dependent test statistics. In this work, we provide a new framework for deriving online multiple test procedures that ensure asymptotical (with respect to the sample size) control of the familywise error rate, regardless of the dependence structure between test statistics. In this context, we give a few concrete examples of such test procedures and discuss their properties. Furthermore, we conduct a simulation study in which the type I error control of these test procedures is also confirmed for a finite sample size, and a gain in power is indicated.

Statistical Methods in Medical Research
University of Bremen (DE)
Deutsche Forschungsgemeinschaft
Peace, Justice and strong institutions
Openalex Percentile: Top 99%
Statistical Methods in Clinical Trials
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Asymptotic online FWER control for dependent test statistics — Werner Brannath, Lasse Fischer, et al. · Statistical Methods in Medical Research (2026) | TGRS Research Map | TGRS