Differential T-cell and monocyte responses in hepatocellular carcinoma treated with regorafenib plus nivolumab: an integrated clinical and biomarker analysis of the phase 2 RENOBATE trial
Regorafenib plus nivolumab (RegoNivo) combination has shown promising anti-cancer activity in multiple cancer types. REBNOBATE trial is a single-arm multicenter phase 2 trial of first-line RegoNivo in patients (pts) with uHCC (NCT04310709). Here we report the clinical outcomes of the RENOBATE study and integrative biomarker analysis using circulating tumor DNA (ctDNA) and single cell RNA sequencing (scRNA-seq) analysis.
Authors
- Jung Yong Hong (ORCID: https://orcid.org/0000-0003-1363-9332)
- Ho Yeong Lim (ORCID: https://orcid.org/0000-0001-9325-2300)
- Han Chu Lee (ORCID: https://orcid.org/0000-0002-7631-4124)
- Baek‐Yeol Ryoo (ORCID: https://orcid.org/0000-0002-9052-833X)
- Seyoung Jung (ORCID: https://orcid.org/0000-0002-0285-5972)
- Jeong Seok Lee (ORCID: https://orcid.org/0000-0001-8261-7044)
- Hong Jae Chon (ORCID: https://orcid.org/0000-0002-6979-5812)
- Beodeul Kang (ORCID: https://orcid.org/0000-0001-5177-8937)
- Richard S. Finn (ORCID: https://orcid.org/0000-0003-2494-2126)
- Hyung‐Don Kim (ORCID: https://orcid.org/0000-0001-9959-0642)
- Deok‐Bog Moon (ORCID: https://orcid.org/0000-0002-8209-3540)
- Min‐Hee Ryu (ORCID: https://orcid.org/0000-0002-1033-1263)
- June‐Young Koh (ORCID: https://orcid.org/0000-0002-2043-6624)
- Changhoon Yoo (ORCID: https://orcid.org/0000-0002-1451-8455)
- Ki‐Hoon Kim (ORCID: https://orcid.org/0000-0002-8654-4046)
- Tae Won Kim (ORCID: https://orcid.org/0000-0001-9522-1997)
Institutions
- Ulsan College (KR)
- University of California, Los Angeles (US)
- Asan Medical Center (KR)
- Samsung Medical Center (KR)
- University of Ulsan (KR)
- CHA University Bundang Medical Center (KR)
- CHA University (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Zenodo (CERN European Organization for Nuclear Research)
- Published
- 2024-11-28
- DOI
- https://doi.org/10.5281/zenodo.8367384
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00