Empagliflozin significantly prevents QTc prolongation due to amitriptyline intoxication
In this study, we determined that empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. This effect was probably due to the opposite effects of these two agents in the intracellular calcium balance. With more clinical trials, the routine use of empagliflozin may be suggested to prevent QT and QTc prolongation in diabetic patients receiving amitriptyline.
Authors
- Veysel Özgür Barış (ORCID: https://orcid.org/0000-0002-3021-8612)
- Adnan Berk Dinçsoy
- Ayşen Erdem (ORCID: https://orcid.org/0000-0003-0980-2088)
- Esra Gedikli
Institutions
- Gaziantep University (TR)
- Hacettepe University (TR)
Publication Details
- Journal
- Cardiovascular journal of South Africa/Cardiovascular journal of Southern Africa
- Published
- 2024-09-01
- DOI
- https://doi.org/10.5830/cvja-2023-017
- Citations
- 6
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.07