A Randomized, Double-Blind, Controlled Clinical Trial of Omega-3 Fatty Acids and Inositol as Monotherapies and in Combination for the Treatment of Pediatric Bipolar Spectrum Disorder in Children Age 5–12
The antimanic and antidepressant effects of the combination treatment of omega-3 FAs and inositol were consistently superior to either treatment used alone. This combination may offer a safe and effective alternative or augmenting treatment for youth with BP spectrum disorder, but more work is needed to confirm the statistical significance of this finding.
Authors
- Atilla Ceranoglu
- Maura DiSalvo (ORCID: https://orcid.org/0000-0002-2793-4888)
- Abigail Farrell (ORCID: https://orcid.org/0000-0003-4411-3288)
- Stephen V. Faraone (ORCID: https://orcid.org/0000-0002-9217-3982)
- Emmaline Cook
- Joseph Biederman (ORCID: https://orcid.org/0000-0001-8233-663X)
- Janet Wozniak (ORCID: https://orcid.org/0000-0002-1250-886X)
- Carrie Vaudreuil (ORCID: https://orcid.org/0000-0002-5971-7554)
- Mai Uchida (ORCID: https://orcid.org/0000-0003-1465-2635)
- Gagan Joshi (ORCID: https://orcid.org/0000-0002-6628-2835)
Institutions
- SUNY Upstate Medical University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Psychopharmacology Bulletin
- Published
- 2025-08-12
- DOI
- https://doi.org/10.64719/pb.4449
- Citations
- 6
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94