Influence of Plasma Concentration of Hsa-Mir-370-3p and Cyp2d6*4 On Equilibrium Concentration of Phenazepam in Patients with Recurrent Depressive Disorder
The effect of genetic polymorphism of the CYP2D6 gene on the efficacy and safety profiles of phenazepam was not demonstrated in a group of 191 patients with recurrent depressive disorder. At the same time, hsa-miR-370-3p does not remain a promising biomarker for assessing the level of CYP2D6 expression, because it does not correlate with encoded isoenzyme activity.
Authors
- Elena Kaverina (ORCID: https://orcid.org/0000-0002-0264-8543)
- Alexey E. Petukhov
- Е. А. Гришина (ORCID: https://orcid.org/0000-0002-5621-8266)
- M. S. Zastrozhin (ORCID: https://orcid.org/0000-0003-0607-4812)
- Dina Klepikov
- E. P. Pankratenko (ORCID: https://orcid.org/0000-0002-2612-439X)
- Evgeny Bryun (ORCID: https://orcid.org/0000-0002-9329-1155)
- Irina V. Bure (ORCID: https://orcid.org/0000-0003-2043-5848)
- S A Pozdniakov
- A V Efimova
- Valentin Yurievich Skryabin (ORCID: https://orcid.org/0000-0002-4942-8556)
- Dmitry Alekseevich Sychev (ORCID: https://orcid.org/0000-0002-4496-3680)
- Smirnov Vv (ORCID: https://orcid.org/0000-0002-8232-6682)
- Kristina Ryzhikova
Institutions
- Russian Medical Academy of Continuous Professional Education (RU)
Publication Details
- Journal
- Psychopharmacology Bulletin
- Published
- 2025-08-12
- DOI
- https://doi.org/10.64719/pb.4420
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00