Neurotrauma induced retinal basement membrane COL4A1 defects are restored by adipose tissue derived mesenchymal stem cell concentrated conditioned medium
These findings collectively identify COL4A1 deficiency as a sensitizing factor for post-traumatic visual dysfunction and demonstrate that ASC-CCM exerts therapeutic effects by preserving retinal vascular structure and modulating inflammatory responses, positioning it as a promising candidate for treating TBI-related ocular neurovascular injury.
Authors
- Manish Kumar (ORCID: https://orcid.org/0000-0002-0855-3406)
- Nobel A. Del Mar
- Rajashekhar Gangaraju (ORCID: https://orcid.org/0000-0002-6664-8286)
- Jordy Gentry
- Pratheepa Kumari Rasiah (ORCID: https://orcid.org/0000-0002-6649-2680)
- Lawrence M. Pfeffer (ORCID: https://orcid.org/0000-0003-2809-1234)
- Anton Reiner (ORCID: https://orcid.org/0000-0002-2146-5232)
Institutions
- University of Tennessee Health Science Center (US)
- Vanderbilt University (US)
- Rayat Bahra University (IN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-15
- DOI
- https://doi.org/10.1186/s13287-025-04804-6
- Primary Topic
- Retinal and Optic Conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00