An Automated Machine Learning Classifier for Early Childhood Caries.

<b>Purpose:</b> The purpose of the study was to develop and evaluate an automated machine learning algorithm (AutoML) for children's classification according to early childhood caries (ECC) status. <b>Methods:</b> Clinical, demographic, behavioral, and parent-reported oral health status information for a sample of 6,404 three- to five-year-old children (mean age equals 54 months) participating in an epidemiologic study of early childhood oral health in North Carolina was used. ECC prevalence (decayed, missing, and filled primary teeth surfaces [dmfs] score greater than zero, using an International Caries Detection and Assessment System score greater than or equal to three caries lesion detection threshold) was 54 percent. Ten sets of ECC predictors were evaluated for ECC classification accuracy (i.e., area under the ROC curve [AUC], sensitivity [Se], and positive predictive value [PPV]) using an AutoML deployment on Google Cloud, followed by internal validation and external replication. <b>Results:</b> A parsimonious model including two terms (i.e., children's age and parent-reported child oral health status: excellent/very good/good/fair/poor) had the highest AUC (0.74), Se (0.67), and PPV (0.64) scores and similar performance using an external National Health and Nutrition Examination Survey (NHANES) dataset (AUC equals 0.80, Se equals 0.73, PPV equals 0.49). Contrarily, a comprehensive model with 12 variables covering demographics (e.g., race/ethnicity, parental education), oral health behaviors, fluoride exposure, and dental home had worse performance (AUC equals 0.66, Se equals 0.54, PPV equals 0.61). <b>Conclusions:</b> Parsimonious automated machine learning early childhood caries classifiers, including single-item self-reports, can be valuable for ECC screening. The classifier can accommodate biological information that can help improve its performance in the future.