Sequential Multiple Assignment Randomized Treatment (SMART) for Bipolar Disorder at Any Phase of Illness and at least Mild Symptom Severity
The efficacy of lithium and divalproex as monotherapy was modest. Adjunctive lamotrigine and quetiapine to either one was well-tolerated and equally effective in reducing bipolar symptomatology, but adjunctive therapy should be initiated as early as possible when depression symptoms are present.
Authors
- Nicole D’Arcangelo
- Jodi Gonzalez Arnold
- Yuanhan Bai (ORCID: https://orcid.org/0000-0003-3574-1346)
- Carla Conroy (ORCID: https://orcid.org/0000-0002-7815-7353)
- Joseph R. Calabrese (ORCID: https://orcid.org/0000-0003-4647-8571)
- Marlon P. Quinones
- Martha Schinagle (ORCID: https://orcid.org/0000-0003-3503-7172)
- Keming Gao (ORCID: https://orcid.org/0000-0003-1130-2461)
- Vivek Singh (ORCID: https://orcid.org/0000-0003-0805-1147)
- Charles L. Bowden
- Thomas J. Prihoda
Institutions
- Texas Tech University (US)
- The University of Texas at San Antonio Health Science Center (US)
Publication Details
- Journal
- Psychopharmacology Bulletin
- Published
- 2025-08-12
- DOI
- https://doi.org/10.64719/pb.4604
- Citations
- 7
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.41