Avirulent Gram-negative Bacteria E. coli K-12 or E. coli C Compared with Gram-positive Virulent Diplococcic Streptoccocus pneumonia

Growth curve of E. coli C is similar to that of the pathogenic Gram positive strain Streptococcus pneumoniae (Sp). In 1928 Dr. Griffith studied Smooth and Rough colonies on blood agar (BA) medium and significance of his observation has been ignored for a long time. In 1944, Dr. Avery et al. have made wrong interpretation of this observation. TCA insoluble precipitation contained only a few nucleotides or at bests a fragment of 0.1 Kb. It is unlikely to contain any genetic character. Recently, Palchaudhuri et al. revived and redefined Dr. Griffith’s Smooth and Rough colonies. These colonies are actually the growth curve of S. pneumoniae. Our objective is to demonstrate a way of combating the pathogen S. pneumoniae by utilizing the knowledge of growth pattern.